Intestinal health is the most determining factor for animal health in general, herd performance and eventually farm profitability. Pathogenic bacteria may colonise the gastrointestinal tract and result in clinical and sub-clinical disease. Reduced feed intake and daily gain, inactivity and decreased social interactions are all observed in animals with bacterial infections.
Livestock producers are often forced to make use of unconventional protein and carbohydrate sources or materials of lower quality. This means that animals are constantly challenged with changing diet compositions and quality, which pause risks for their health.
Stress often leads to health challenges and intestinal disorders and is linked with the ‘leaking gut’ syndrome. The end-product is subclinical inflammation which can cost up to 30% of the animal’s energy requirements.
Regulation, food safety and animal welfare are also setting up new trends towards limitations or restrictions of antibiotic usage for disease treatment, medicated feed, zinc oxide etc.
By controlling the microflora in the lumen and strengthening the intestinal epithelium integrity, Lumance offers a comprehensive GUT HEALTH MANAGEMENT program that aims at reducing medication or cocktails of medication.
Lumance is a complex structure, which contains the newest generation of butyrate, combining slow release and protection technologies, ensuring that acids, medium- chain fatty acids, essential oils, anti-inflammatory compounds and polyphenols are delivered in a gut active way for powerful and effective antibacterial control, high quality tight junctions, neutralisation of the produced ROS and tempering of the inflammatory cytokine production.
Lumance is an effective and powerful tool to reduce inflammation, promote villi growth, tighten the intestinal junction and stabilise the microflora.
1. Reinforce gut integrity
The area of the intestinal wall carries an important responsibility in selecting what can be absorbed and what should remain outside the body of the animal. To put this into the right perspective, it is important to realize that the surface of the intestinal tract is 300 times the size of the surface of the skin. At the same time, it should give the similar level of protection against invaders, while being highly permeable in order to absorb nutrients.
Tight junctions, a complex protein structure formed between epithelium cells, play a crucial role in protecting the insides of the animal from the challenges present in the lumen. Many molecules present in the digestive tract (free radicals, toxins,…) put these tight junctions under continuous stress, which increases the risk of passage of toxins.
The totality of the intestinal integrity can additionally be protected by means of an intestinal coating. This protective layer, which is the result of complexation of tannin rich extracts with proteins present in the mucus layer, can reduce the impact of invading mechanisms on the intestinal integrity itself.
The targeted release butyrate:
2. Reduce inflammatory response
The anti-inflammatory properties of butyric acid are complemented by plant extracts rich in alkaloids and essential oils found in the unique Lumance recipe. Their efficacy and synergistic effect were demonstrated both in vitro and in vivo.
Fig a) shows In vitro inhibition of LPS induced inflammation in macrophage producing cell lines by Lumance® expressed as reduction of Nitric Oxide, b) demonstrates the synergistic effect of Lumance® and c) shows and In vivo demonstration of the anti-inflammatory effect of Lumance® (gene expression of the chicken Host Defense Peptide, β-defensin 9 - AvBD9)
3. Balance the lumen and its gastrointestinal microflora
Lumance has been carefully designed to reduce the impact of pathogens and support the growth of beneficial bacteria. The graph below shows the direct antibacterial effect of Lumance in vitro against a) Clostridium perfringens and b) Salmonella Typhimurium
4. Protect against ROS
Butyrate stimulates endogenous glutathione release which is the most important antioxidant in the animal’s metabolism. The plant extracts and essential oils added in Lumance have been selected for their antioxidant activity and oxidative stress inhibitory effect, which complement those exerted by butyrate.
It is critical to develop cost effective antibiotic alternative strategies to ensure the long-term sustainability of animal production. Dr. Alireza Khadem, Research & Technical Manager Poultry at Innovad and PhD researcher at the University of Ghent tested the anti-inflammatory activity of Lumance® and the effect of its three main ingredients (fatty acids, essential oils and plant extracts) individually.