Coccidiosis is a burdensome challenge for the global poultry production and existing traditional coccidiosis prevention strategies encounter several challenges. The Aflocox® range is a novel tool towards the management of coccidial risk, taking into consideration the particulars of different production systems. It provides an alternative and can be part of a complementary approach towards the mitigation of coccidial risk, by harnessing the synergistic effect of selected plant bio-actives.
Aflocox® interferes with the Eimeria cell wall synthesis. Aflocox® contains triterpenoid saponins that bind to the cholesterol of the protozoan cell membrane. This leads to incomplete oocyst wall synthesis and eventually to partial cell lysis and cell death.
Aflocox® contains several bio-active immunomodulatory compounds that reinforce the bird’s immunity during coccidial infection.
Reactive oxidative species are produced by the host’s cellular immune response during invasion by Eimeria species. Although this plays a role in defending against parasitic infections, when concentrations exceed a certain level, they cause tissue damage and cytotoxicity. The antioxidant bio-actives within Aflocox® can alleviate excessive oxidative stress.
Upon invasion of Eimeria, a strong inflammatory response is induced which results in destruction of the intestinal villi, diarrhoea, hemorrhage cases and, death in severe cases. The plant bio-actives within Aflocox® reduce the acute inflammatory response during coccidial infection.